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The Many Loves of Bradley Cooper

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Actors Bradley Cooper and Zoe Saldana arrive at the Los Angeles premiere of "The Words" at ArcLight Cinemas on September 4, 2012 in Hollywood, California.

And so another Bradley Cooper breakup has come to pass.

The actor’s romance with “The Words” co-star Zoe Saldana has hit a second reported skid, according to Page Six, fizzling out before the New Year.

[Related: Celebrity Breakups of 2012]

The ol’ “conflicting schedules” excuse is cited as the reason for the breakup, with Cooper said to be in Prague shooting a commercial and Saldana fresh off a vacay in South Beach with pals.

“Zoe had planned to spend the holidays with Bradley and his family in Europe," a source tells Page Six. "They all were going to Paris, but things didn’t work out between them. Zoe spent New Year’s Eve with friends in Miami.”

But there’s a silver lining for handsome Bradley – and it’s his little black book. We’d never insinuate that Cooper would put a former love back in rotation, but he and Zoe did attempt to make their relationship work twice. (They split in March 2012, but reconciled in September.)

Shall we recap a few of his more famous off-screen love interests?

Jennifer Lopez: Peaking in October 2011, word had it that Cooper was sweet on Lopez following news of her divorce from crooner Mark Anthony. Dates included trips to high-end Manhattan restaurants, Miami fashion shows, and other fare suitable for the actress/singer/entrepreneur. The duo lost momentum, however, and Cooper was seen briefly with stunning French actress Melanie Laurent before meeting Saldana.

Olivia Wilde: Before J.Lo, another raven-haired beauty caught Bradley’s attention – a newly divorced Olivia Wilde. Jason Sudeikis’ current beloved turned up at the New York premiere of “The Hangover II” in June of 2011, though she was simultaneously thought to be eyeing Justin Timberlake.

Renee Zellweger: The Academy-Award-winning blonde occupies quite a bit of space on the Cooper love timeline. Sparking on the 2006 set of thriller “Case 39,” delays held the movie up to a 2010 release in the U.S. When making promotional rounds at the time, it was reported the pair had already been cohabitating for a year. Dinner dates, vacations, and even family visits were caught on camera, but neither Bradley nor Renee would officially acknowledge their romance. Sadly, the end of the road came in March 2011, with Us Weekly blaming the split on his newly cemented leading man status.

Cameron Diaz: Call it a fling, but any time spent with Cammy D is worth noting! Bradley and Cameron hung out together in the fall of 2007, enjoying outings that included double dating at football games with a then-married Ashton Kutcher and Demi Moore.

Jennifer Esposito: Not only does “Blue Bloods” actress Esposito rank as the first high-profile mate for Cooper, but she even got him to put a ring on it. Jennifer and Bradley were married in December 2006. And split in May 2007. “It was just something that happened," Cooper later explained to Howard Stern of their short union. “The good thing is, we both realized it.”

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